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Mammary analogue secretory carcinoma (MASC) of salivary glands is a newly recognised form of carcinoma (cancer that develops in the tissues that line the organs) that develops in the salivary glands. Salivary glands are responsible for the production of saliva, which is a fluid that aids in digestion, prevents your mouth from becoming too dry and supports healthy teeth.
In humans, there are three pairs of major salivary glands located behind the jaw: parotid, sublingual and submandibular. The parotid glands are largest, and are found in the cheeks. The main role of the parotid glands is to initiate the first part of digestion. In most cases, MASC of the salivary glands is found in the parotid glands. The sublingual glands are the smallest and are found on each side of the tongue. These glands produce the least amount of saliva. The submandibular glands are located on the floor of our mouths on each side, and produce the most saliva. There are also several minor salivary glands found in the lips, cheeks, mouth and throat.
This type of cancer gets its name from an equally rare and also newly recognised type of cancer called secretory carcinoma of the breast, which is predominantly found in children. MASC of salivary glands shares genetic and cellular features with this type of cancer.
MASC of salivary glands is usually diagnosed in adults, but it can be diagnosed at any age.
If MASC of salivary glands is detected, it will be staged and graded based on size, metastasis (whether the cancer has spread to other parts of the body) and how the cancer cells look under the microscope. Staging and grading helps your doctors determine the best treatment for you.
Cancers can be staged using the TNM staging system:
This system can also be used in combination with a numerical value, from stage 0-IV:
Cancers can also be graded based on the rate of growth and how likely they are to spread:
Once your tumour has been staged and graded, your doctor may recommend genetic testing, which analyses your tumour DNA and can help determine which treatment has the greatest chance of success. They will then discuss the most appropriate treatment option for you.
Treatment is dependent on several factors, including location, stage of disease and overall health.
Treatment options for MASC of salivary glands may include:
For more information on the treatment options, please refer to the Rare Cancers Australia treatment options page.
Because of how rare MASC of salivary glands is, there has been limited research into the risk factors of this disease. However, genetic predisposition has been identified as a potential factor that may increase the likelihood of developing this disease.
Symptoms of MASC in the salivary glands may include:
Not everyone with the symptoms above will have cancer but see your general practitioner (GP) if you are concerned.
If your doctor suspects you have a MASC of the salivary glands, they will order a range of diagnostic tests to confirm the diagnosis, and refer you to a specialist for treatment.
Your doctor will collect your overall medical history, as well as your current symptoms. Following this, they may examine your body to check for any abnormalities.
The doctor will take images of your body using magnetic resonance imaging (MRI), a computed tomography scan (CT scan), x-ray and/or ultrasound, depending on where it is suspected the cancer is. The doctor may also look at other parts of the body and looks for signs of metastasis. Additionally, a blood test may be taken to assess your overall health and help guide treatment decisions.
Once the location of the cancer has been identified, the doctor will perform a biopsy to remove a section of tissue using a needle. Once a sample has been removed, it will be sent to a lab and analysed for cancer cells.
While it is not possible to predict the exact course of the disease, your doctor may be able to give you a general idea based on the rate and depth of tumour growth, susceptibility to treatment, age, overall fitness, and medical history. Generally, early-stage MASC of the salivary glands have a better prognosis and survival rates. However, if the cancer is advanced and has spread, the prognosis may not be as good and there may be a higher risk of cancer recurrence. It is very important to discuss your individual circumstances with your doctor to better understand your prognosis.
Some references are to overseas websites. There may be references to drugs and clinical trials that are not available here in Australia.
Page last updated: 22/04/2022